The College is home to six departments and a number of state-of-the-art teaching and research labs, three large research collections (Herpetology, Entomology, and Botany), the University Planetarium, the James H. Oliver, Jr. Institute for Coastal Plain Science, the U.S. National Tick Collection from the Smithsonian Institute, the Applied Coastal Research Laboratory on Skidaway Island, and the Foram Sustainable Aquaponics Research Center.

The Chemistry and Biochemistry Department is accredited by the American Chemical Society.

The College of Science and Mathematics collection archives college and department news as well as research works produced by the faculty of the College.

Visit https://cosm.georgiasouthern.edu/about/ for additional information about the College of Science and Mathematics.