Bestatin: Three Decades of Synthetic Strategies
Document Type
Article
Publication Date
1-1-2007
Publication Title
Current Organic Chemistry
DOI
10.2174/138527207780059277
ISSN
1875-5348
Abstract
Bestatin (ubenimex) is a dipeptide that can treat a variety of diseases. Over the last thirty years synthetic chemists have developed an assortment of routes to optically pure (-)-Bestatin. Many strategies include the use of pure starting materials like sugars and amino acids. In addition, the utilization of chiral auxiliary groups have been implemented to achieve an increase in stereoselectivity and to simplify the purification process. Lastly, asymmetric catalysis using enzymes or inorganic catalysts has also been used to afford the desired stereochemistry. This review will cover 23 synthetic strategies to (-)-Bestatin through the year 2005.
Recommended Citation
Feske, Brent D..
2007.
"Bestatin: Three Decades of Synthetic Strategies."
Current Organic Chemistry, 11 (5): 483-496: Bentham Science Publishers.
doi: 10.2174/138527207780059277 source: http://www.eurekaselect.com/58859/article
https://digitalcommons.georgiasouthern.edu/chem-facpubs/133
