Date

2019

Major

Chemistry (B.S.)

Document Type and Release Option

Thesis (restricted to Georgia Southern)

Faculty Mentor

Dr. Beverly Briggs Penland

Abstract

In this work, Pd nanoparticles were formed on the surface of CPd4 peptide-functionalized Au nanorods as a biomimetic approach to create nanomaterials under environmentally-friendly conditions for potential use as a catalyst in Suzuki coupling and other carbon-carbon cross-coupling reactions. Biomolecule ligands of peptides have shown to control the shape and size of metal nanoparticles. In addition, modification of the amino acid sequence of peptides can manipulate the synthesis of metal nanoparticles, thus providing more control over the metal nanoparticle size, shape, and function. Previous studies using Pd4 (TSNAVHPTLRHL) peptide-capped Pd nanoparticles have shown high activity for various C-C reactions in water and at room temperature. One disadvantage to these studies, however, was the lack of reactivity with chlorinated starting materials. The use of chlorinated starting materials for C-C cross-coupling reactions is highly sought after due to the abundance and low cost of chlorinated substrates. As a result, research in plasmonic catalysis has evolved to fill this need. For this project, plasmonic Au nanorods were functionalized with Pd4 peptide through the addition of a cysteine to the N-terminus as thiol groups are known to bind to Au. CPd4-functionalized Au nanorods serve as a scaffold for the generation of Pd nanoparticles. The size, and shape of Pd nanoparticle formation on Au nanorods was shown through electron microscopy studies to be dependent on the solvent the Au nanorods were dispersed in and concentration of peptide on the Au nanorod surface. Thus this synthesis can potentially be tuned and designed for catalytic optimization.

Thesis Summary

In this work, Pd nanoparticles were formed on the surface of CPd4 peptide-functionalized Au nanorods as a biomimetic approach to create nanomaterials under environmentally-friendly conditions for potential use as a catalyst in Suzuki coupling and other carbon-carbon cross-coupling reactions. Biomolecule ligands of peptides have shown to control the shape and size of metal nanoparticles. In addition, modification of the amino acid sequence of peptides can manipulate the synthesis of metal nanoparticles, thus providing more control over the metal nanoparticle size, shape, and function. Previous studies using Pd4 (TSNAVHPTLRHL) peptide-capped Pd nanoparticles have shown high activity for various C-C reactions in water and at room temperature. One disadvantage to these studies, however, was the lack of reactivity with chlorinated starting materials. The use of chlorinated starting materials for C-C cross-coupling reactions is highly sought after due to the abundance and low cost of chlorinated substrates. As a result, research in plasmonic catalysis has evolved to fill this need. For this project, plasmonic Au nanorods were functionalized with Pd4 peptide through the addition of a cysteine to the N-terminus as thiol groups are known to bind to Au. CPd4-functionalized Au nanorods serve as a scaffold for the generation of Pd nanoparticles. The size, and shape of Pd nanoparticle formation on Au nanorods was shown through electron microscopy studies to be dependent on the solvent the Au nanorods were dispersed in and concentration of peptide on the Au nanorod surface. Thus this synthesis can potentially be tuned and designed for catalytic optimization.

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