Honors College Theses
Publication Date
4-4-2019
Major
Chemistry (B.S.)
Document Type and Release Option
Thesis (restricted to Georgia Southern)
Faculty Mentor
Dr. Beverly Briggs Penland
Abstract
In this work, Pd nanoparticles were formed on the surface of CPd4 peptide-functionalized Au nanorods as a biomimetic approach to create nanomaterials under environmentally-friendly conditions for potential use as a catalyst in Suzuki coupling and other carbon-carbon cross-coupling reactions. Biomolecule ligands of peptides have shown to control the shape and size of metal nanoparticles. In addition, modification of the amino acid sequence of peptides can manipulate the synthesis of metal nanoparticles, thus providing more control over the metal nanoparticle size, shape, and function. Previous studies using Pd4 (TSNAVHPTLRHL) peptide-capped Pd nanoparticles have shown high activity for various C-C reactions in water and at room temperature. One disadvantage to these studies, however, was the lack of reactivity with chlorinated starting materials. The use of chlorinated starting materials for C-C cross-coupling reactions is highly sought after due to the abundance and low cost of chlorinated substrates. As a result, research in plasmonic catalysis has evolved to fill this need. For this project, plasmonic Au nanorods were functionalized with Pd4 peptide through the addition of a cysteine to the N-terminus as thiol groups are known to bind to Au. CPd4-functionalized Au nanorods serve as a scaffold for the generation of Pd nanoparticles. The size, and shape of Pd nanoparticle formation on Au nanorods was shown through electron microscopy studies to be dependent on the solvent the Au nanorods were dispersed in and concentration of peptide on the Au nanorod surface. Thus this synthesis can potentially be tuned and designed for catalytic optimization.
Thesis Summary
In this work, Pd nanoparticles were formed on the surface of CPd4 peptide-functionalized Au nanorods as a biomimetic approach to create nanomaterials under environmentally-friendly conditions for potential use as a catalyst in Suzuki coupling and other carbon-carbon cross-coupling reactions. Biomolecule ligands of peptides have shown to control the shape and size of metal nanoparticles. In addition, modification of the amino acid sequence of peptides can manipulate the synthesis of metal nanoparticles, thus providing more control over the metal nanoparticle size, shape, and function. Previous studies using Pd4 (TSNAVHPTLRHL) peptide-capped Pd nanoparticles have shown high activity for various C-C reactions in water and at room temperature. One disadvantage to these studies, however, was the lack of reactivity with chlorinated starting materials. The use of chlorinated starting materials for C-C cross-coupling reactions is highly sought after due to the abundance and low cost of chlorinated substrates. As a result, research in plasmonic catalysis has evolved to fill this need. For this project, plasmonic Au nanorods were functionalized with Pd4 peptide through the addition of a cysteine to the N-terminus as thiol groups are known to bind to Au. CPd4-functionalized Au nanorods serve as a scaffold for the generation of Pd nanoparticles. The size, and shape of Pd nanoparticle formation on Au nanorods was shown through electron microscopy studies to be dependent on the solvent the Au nanorods were dispersed in and concentration of peptide on the Au nanorod surface. Thus this synthesis can potentially be tuned and designed for catalytic optimization.
Recommended Citation
Wagner, John Tyler, "Synthesis of Gold Nanorods with CPd4 Peptide-Capped Palladium Nanoparticles Functionalization for Carbon-Carbon Cross-Coupling Reactions" (2019). Honors College Theses. 398.
https://digitalcommons.georgiasouthern.edu/honors-theses/398
