Hydration of Terminal Alkynes with Molecular Iodine: A Mechanistic Investigation
Primary Faculty Mentor’s Name
Karelle Aiken
Proposal Track
Student
Session Format
Poster
Abstract
Our research group has reported that when using 5-oxo-1-alkynes in an iodine-initiated hydration of terminal alkynes under mild and ambient conditions, it can yield methyl ketones. Using molecular iodine under such conditions, in comparison to the traditional use of a metal catalyst, is more novel, inexpensive, and environmentally friendly. Our findings about the mechanism of this reaction have opened the window to developing methodologies for building blocks based on biologically relevant molecules such as furan analogs and α-substituted ketones. Both of these units can be found in pharmaceuticals and naturally occurring compounds. As such, the iodine-initiated hydration warrants further exploration and here-in we report our initial results with iodine-mediated procedures for furan and ketone derivatives.
Location
Concourse/Atrium
Presentation Year
2014
Start Date
11-15-2014 2:55 PM
End Date
11-15-2014 4:10 PM
Publication Type and Release Option
Presentation (Open Access)
Recommended Citation
Tate, Katrina; Lee, Zachary; and Afeku, Kevin, "Hydration of Terminal Alkynes with Molecular Iodine: A Mechanistic Investigation" (2014). Georgia Undergraduate Research Conference (2014-2015). 98.
https://digitalcommons.georgiasouthern.edu/gurc/2014/2014/98
Hydration of Terminal Alkynes with Molecular Iodine: A Mechanistic Investigation
Concourse/Atrium
Our research group has reported that when using 5-oxo-1-alkynes in an iodine-initiated hydration of terminal alkynes under mild and ambient conditions, it can yield methyl ketones. Using molecular iodine under such conditions, in comparison to the traditional use of a metal catalyst, is more novel, inexpensive, and environmentally friendly. Our findings about the mechanism of this reaction have opened the window to developing methodologies for building blocks based on biologically relevant molecules such as furan analogs and α-substituted ketones. Both of these units can be found in pharmaceuticals and naturally occurring compounds. As such, the iodine-initiated hydration warrants further exploration and here-in we report our initial results with iodine-mediated procedures for furan and ketone derivatives.
