Novel Photodynamic Therapy Agents: Biochemical Analysis
Primary Faculty Mentor’s Name
C. Michele Davis McGibony
Proposal Track
Student
Session Format
Paper Presentation
Abstract
Photodynamic therapy agents are used in all manners of medical professions from oncologists to dermatologists. These compounds reduce the size of tumors, treat skin diseases, and inactivate certain viruses including HIV-1 and HSV-1. Their mode of action is to either kill tumors or viruses by direct cell death, loss of oxygen, loss of the nutrient supply, or loss of immune system responses. In the past, organic dyes, aromatic hydrocarbons, polypyrolics complexes, and other compounds were the focus of research in this field, but due to limitations in their biological properties, research has slowed in this area. Recently it has come to light that porphyrin compounds with transition metals in their core have great potential as photodynamic therapy drugs. This laboratory has been investigating the potential of novel copper and manganese porphyrins, as new photodynamic therapy drugs. The porphyrin compounds were activated via laser at 488 nanometers, and the rate of DNA cleavage of two different plasmids (pBR322 and pUC19) was measured via DNA gel electrophoresis and UV-Visible spectrometry.
Keywords
Photodynamic therapy, Biochemistry, Copper and manganese
Location
Room 1909
Presentation Year
2014
Start Date
11-15-2014 11:05 AM
End Date
11-15-2014 12:05 PM
Publication Type and Release Option
Presentation (Open Access)
Recommended Citation
Pullen, Eboni and Davis McGibony, C. Michele, "Novel Photodynamic Therapy Agents: Biochemical Analysis" (2014). Georgia Undergraduate Research Conference (2014-2015). 62.
https://digitalcommons.georgiasouthern.edu/gurc/2014/2014/62
Novel Photodynamic Therapy Agents: Biochemical Analysis
Room 1909
Photodynamic therapy agents are used in all manners of medical professions from oncologists to dermatologists. These compounds reduce the size of tumors, treat skin diseases, and inactivate certain viruses including HIV-1 and HSV-1. Their mode of action is to either kill tumors or viruses by direct cell death, loss of oxygen, loss of the nutrient supply, or loss of immune system responses. In the past, organic dyes, aromatic hydrocarbons, polypyrolics complexes, and other compounds were the focus of research in this field, but due to limitations in their biological properties, research has slowed in this area. Recently it has come to light that porphyrin compounds with transition metals in their core have great potential as photodynamic therapy drugs. This laboratory has been investigating the potential of novel copper and manganese porphyrins, as new photodynamic therapy drugs. The porphyrin compounds were activated via laser at 488 nanometers, and the rate of DNA cleavage of two different plasmids (pBR322 and pUC19) was measured via DNA gel electrophoresis and UV-Visible spectrometry.
