A General Synthesis of Bis-indolylpiperazine-2,5-diones

Authors

• Stephen N. Crooke, Georgia Southern UniversityFollow
• Christine Whitlock, Georgia Southern UniversityFollow

Document Type

Article

Publication Date

2012

Publication Title

Molecules

DOI

10.3390/molecules171214841

ISSN

1420-3049

Abstract

The one-pot synthesis of three dragmacidin derivatives is reported. Sarcosine anhydride (4) is brominated and immediately reacted with the corresponding indole to produce the products, namely 3,6-bis(5′-methoxy-3′-indolyl)-1,4-dimethylpiperazine-2,5-dione (1), 3,6-bis(7′-methyl-3′-indolyl)-1,4-dimethylpiperazine-2,5-dione (2) and 3,6-bis-(6′-chloro-3′-indolyl)-1,4-dimethylpiperazine-2,5-dione (3), which are characterized by ¹H-NMR.

Comments

Article obtained from Molecules, an open access journal.

Recommended Citation

Crooke, Stephen N., Christine Whitlock. 2012. "A General Synthesis of Bis-indolylpiperazine-2,5-diones." Molecules, 17 (12): 14841-14845: MDPI. doi: 10.3390/molecules171214841 source: https://www.mdpi.com/1420-3049/17/12/14841 pmid: 23519256
https://digitalcommons.georgiasouthern.edu/chem-facpubs/34

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