Document Type
Article
Publication Date
2010
Publication Title
Journal of Combinatorial Chemistry
DOI
10.1021/cc1000105
ISSN
1520-4774
Abstract
A library of oligomeric compounds was synthesized based on the imidazole-4,5-dicarboxylic acid scaffold along with amino acid esters and chiral diamines derived from amino acids. The final compounds incorporate nonpolar amino acids (Leu, Phe, Trp), polar amino acids (Ser, Asp, Arg), and neutral amino acids (Gly, Ala), and were designed to be useful in screening for inhibitors of protein−protein interactions. Many of the protected and deprotected oligomers show evidence of conformational isomers persistent at room temperature in aqueous solution. A total of 317 final oligomers, out of 441 targeted compounds, were obtained in high analytical purity and of sufficient quantity to submit them for high-throughput screening as part of the NIH Roadmap.
Recommended Citation
Xu, Zhigang, John C. DiCesare, Paul W. Baures.
2010.
"Parallel Synthesis of an Oligomeric Imidazole-4,5-Dicarboxamide Library."
Journal of Combinatorial Chemistry, 12 (2): 248-254: American Chemical Society.
doi: 10.1021/cc1000105 source: https://pubs.acs.org/doi/10.1021/cc1000105
https://digitalcommons.georgiasouthern.edu/chem-facpubs/13
Comments
This is an Accepted Author Manuscript obtained from PMC. The publisher's final edited version of this article is available at Journal of Combinatorial Chemistry.