Title

Statistical Considerations for Clinical Trials During COVID-19: Confirmatory Adaptive Platform Trial (CAPT) Design for COVID-19 Treatment (Part III)

Document Type

Article

Publication Date

5-11-2020

Publication Title

LinkedIn

Abstract

Part III of the article that describes confirmatory adaptive platform trial (CAPT) design for COVID-19 treatment development. We continue with the section on statistical methods for CAPT design, covering topics on sequential p-value and monitoring, point estimate and confidence interval, multiplicity in hypothesis testing, missing data handling, and use of non-concurrent controls. We finish the article with discussion on controversy of stochastic curtailment, inappropriateness of adaptive Bayesian design, and free software for group sequential designs.

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