Statistical Considerations for Clinical Trials During COVID-19: Confirmatory Adaptive Platform Trial (CAPT) Design for COVID-19 Treatment (Part II)

Document Type

Article

Publication Date

5-10-2020

Publication Title

LinkedIn

Abstract

Part II of the article that describes confirmatory adaptive platform trial (CAPT) design for COVID-19 treatment development. We describe the methodological foundation of adaptive designs. We provide statistical methods for CAPT design, covering topics on sequential randomizations, adaptive group sequential designs, and sample size adjustment.

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