Biostatistics, Epidemiology & Environmental Health Sciences: Faculty Publications
Statistical Considerations for Clinical Trials During COVID-19: Confirmatory Adaptive Platform Trial (CAPT) Design for COVID-19 Treatment (Part III)
Document Type
Article
Publication Date
5-11-2020
Publication Title
Abstract
Part III of the article that describes confirmatory adaptive platform trial (CAPT) design for COVID-19 treatment development. We continue with the section on statistical methods for CAPT design, covering topics on sequential p-value and monitoring, point estimate and confidence interval, multiplicity in hypothesis testing, missing data handling, and use of non-concurrent controls. We finish the article with discussion on controversy of stochastic curtailment, inappropriateness of adaptive Bayesian design, and free software for group sequential designs.
Recommended Citation
Liu, Qing, Karl E. Peace.
2020.
"Statistical Considerations for Clinical Trials During COVID-19: Confirmatory Adaptive Platform Trial (CAPT) Design for COVID-19 Treatment (Part III)."
LinkedIn.
source: Linkedin.com
https://digitalcommons.georgiasouthern.edu/bee-facpubs/165
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