Fabrication of 5-fluorouracil (Fu) Encapsulating Polycaprolactone (Pcl) Nanoparticles (Nps) for Implementing Targeted Drug Delivery Systems

Session Format

Poster Session (90 and 30 minutes)

Location

Lobby

Abstract for the conference program

We report the fabrication of 5-Fluorouracil (FU) encapsulating Polycaprolactone (PCL) Nanoparticles (NPs) for implementing targeted drug delivery systems. PCL is chosen as the base polymer because of its biocompatibility and biodegradability, meaning that it will safely break down in the body after it serves its function without the need for surgical removal. PCL is also favorable due to its slow-degradation rate and low melting point. In previous experiments, success was achieved in encapsulating FU in PCL nanofibers using a coaxial electrospinning technique. However, the fiber structure is inconvenient for insertion into the body, and nanospheres can easily be injected into the blood stream and directly targeted to the tumor site. Therefore, the research progressed toward nanospheres. The MECC electrospinning machine was used to electrospray drug particles, while a nanoemulsion method was performed on the suspended drug crystals and a PCL solution to create the Polycaprolactone Nanoparticles. A nanoemulsion method is favorable due to the high stability of remaining in the emulsion state for a long period of time, compared to normal emulsions which often quickly re-separate and do not result in nano-sized particles. The purpose of the following experiments is to find the parameters that will manufacture the smallest possible Nanoparticles (NPs) for the sustained, controlled delivery of chemotherapy drugs to cancer cells.

Proposal Track

Research Project

Start Date

3-3-2017 5:00 PM

End Date

3-3-2017 6:30 PM

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Mar 3rd, 5:00 PM Mar 3rd, 6:30 PM

Fabrication of 5-fluorouracil (Fu) Encapsulating Polycaprolactone (Pcl) Nanoparticles (Nps) for Implementing Targeted Drug Delivery Systems

Lobby

We report the fabrication of 5-Fluorouracil (FU) encapsulating Polycaprolactone (PCL) Nanoparticles (NPs) for implementing targeted drug delivery systems. PCL is chosen as the base polymer because of its biocompatibility and biodegradability, meaning that it will safely break down in the body after it serves its function without the need for surgical removal. PCL is also favorable due to its slow-degradation rate and low melting point. In previous experiments, success was achieved in encapsulating FU in PCL nanofibers using a coaxial electrospinning technique. However, the fiber structure is inconvenient for insertion into the body, and nanospheres can easily be injected into the blood stream and directly targeted to the tumor site. Therefore, the research progressed toward nanospheres. The MECC electrospinning machine was used to electrospray drug particles, while a nanoemulsion method was performed on the suspended drug crystals and a PCL solution to create the Polycaprolactone Nanoparticles. A nanoemulsion method is favorable due to the high stability of remaining in the emulsion state for a long period of time, compared to normal emulsions which often quickly re-separate and do not result in nano-sized particles. The purpose of the following experiments is to find the parameters that will manufacture the smallest possible Nanoparticles (NPs) for the sustained, controlled delivery of chemotherapy drugs to cancer cells.