Exploring the Photophysical Properties of Prodrug Delivery in Cationic Micelles
Location
Poster Session 1 (Henderson Library)
Session Format
Poster Presentation
Your Campus
Statesboro Campus- Henderson Library, April 20th
Academic Unit
Department of Chemistry
Research Area Topic:
Natural & Physical Sciences - Chemistry
Co-Presenters and Faculty Mentors or Advisors
Karelle S. Aiken, Shainaz M. Landge, and Debanjana Ghosh
Abstract
The use of drug delivery strategies offers potential and useful routes for increasing the effectiveness of chemotherapeutics through pharmacokinetics and bio-distribution. Nanoscale materials of all kinds including micelles, dendrimers, liposomes and more have been utilized as drug carries.A main component to such systems is the capability to control the drug release, aiding in lowering the side effects and increasing the efficiency of every-day drugs. In this study, cationic alkyltrimethylammonium bromide micelles including dodecyltrimethylammonium bromide (DTAB), tetradecyltrimethylammonium bromide (TTAB), and cetyltrimethylammonium bromide (CTAB) were utilized as the drug delivery apparatus to understand the biological relevance of a triazole based prodrug in a micellar mixture through its physicochemical properties. To do this, fluorescence spectroscopic technique was used to monitor the changes in the photophysical properties of the triazole molecule. The surfactants mimic the biological systems and give a better understanding of how the molecules will interact in vivo. With the information gathered from repeated fluorescence testing; it was consistent that the moleculewas able to enter the micellar system. Further experiments utilize dynamic light scattering techniques and fluorescence anisotropy will aid in determining the location of the prodrug in the micelle.
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
Presentation Type and Release Option
Presentation (Restricted to Georgia Southern)
Start Date
4-20-2022 10:00 AM
End Date
4-20-2022 11:30 AM
Recommended Citation
Merhar, Abbigail, "Exploring the Photophysical Properties of Prodrug Delivery in Cationic Micelles" (2022). GS4 Georgia Southern Student Scholars Symposium. 34.
https://digitalcommons.georgiasouthern.edu/research_symposium/2022/2022/34
Exploring the Photophysical Properties of Prodrug Delivery in Cationic Micelles
Poster Session 1 (Henderson Library)
The use of drug delivery strategies offers potential and useful routes for increasing the effectiveness of chemotherapeutics through pharmacokinetics and bio-distribution. Nanoscale materials of all kinds including micelles, dendrimers, liposomes and more have been utilized as drug carries.A main component to such systems is the capability to control the drug release, aiding in lowering the side effects and increasing the efficiency of every-day drugs. In this study, cationic alkyltrimethylammonium bromide micelles including dodecyltrimethylammonium bromide (DTAB), tetradecyltrimethylammonium bromide (TTAB), and cetyltrimethylammonium bromide (CTAB) were utilized as the drug delivery apparatus to understand the biological relevance of a triazole based prodrug in a micellar mixture through its physicochemical properties. To do this, fluorescence spectroscopic technique was used to monitor the changes in the photophysical properties of the triazole molecule. The surfactants mimic the biological systems and give a better understanding of how the molecules will interact in vivo. With the information gathered from repeated fluorescence testing; it was consistent that the moleculewas able to enter the micellar system. Further experiments utilize dynamic light scattering techniques and fluorescence anisotropy will aid in determining the location of the prodrug in the micelle.
