Exploring the delivery of a small heterocyclic orgonomolecules using non-ionic micelles
Location
Poster Session 2 (Henderson Library)
Session Format
Poster Presentation
Your Campus
Statesboro Campus- Henderson Library, April 20th
Academic Unit
Department of Chemistry
Research Area Topic:
Natural & Physical Sciences - Chemistry
Co-Presenters and Faculty Mentors or Advisors
Dr. Shainaz Landge
Dr. Debanjana ghosh
Abstract
The use of small hydrophobic organic molecules as active pharmaceutical ingredients in oral formulation is continually gaining grounds because they have shown to be versatile and biologically active by binding to specific receptor site. Their use in medication is currently being made possible by employing certain devices or supramolecular structures called Drug Delivery Systems (DDS) that can help transport drugs to their active site while ensuring that they remain unchanged during the process. Surfactants are amphipathic molecules which can form self-organized assemblies called micelles based on their concentration and pH. Micelles of this surfactants are capable of increasing solubility of hydrophobic molecules by providing an environment that facilitates ‘host-guest’ interaction which is being exploited in this study. Our research focuses on strategically synthesizing small heterocyclic compounds that are adaptable or compatible to drug ‘carriers/transporters’ to get them to their target sites. The study involves using microwave assisted click chemistry to synthesize triazole compounds and utilizing non-micelles having polar and non-polar compartment to encapsulate them. A photophysical study was carried out by using steady state fluorescence spectroscopy to evaluate the changes experienced by our triazole derivatives while interacting with the different components within the micellar environment and share in this conference.
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
Presentation Type and Release Option
Presentation (File Not Available for Download)
Start Date
4-20-2022 1:30 PM
End Date
4-20-2022 3:00 PM
Recommended Citation
Fasusi, Emmanuel T., "Exploring the delivery of a small heterocyclic orgonomolecules using non-ionic micelles" (2022). GS4 Georgia Southern Student Scholars Symposium. 31.
https://digitalcommons.georgiasouthern.edu/research_symposium/2022/2022/31
Exploring the delivery of a small heterocyclic orgonomolecules using non-ionic micelles
Poster Session 2 (Henderson Library)
The use of small hydrophobic organic molecules as active pharmaceutical ingredients in oral formulation is continually gaining grounds because they have shown to be versatile and biologically active by binding to specific receptor site. Their use in medication is currently being made possible by employing certain devices or supramolecular structures called Drug Delivery Systems (DDS) that can help transport drugs to their active site while ensuring that they remain unchanged during the process. Surfactants are amphipathic molecules which can form self-organized assemblies called micelles based on their concentration and pH. Micelles of this surfactants are capable of increasing solubility of hydrophobic molecules by providing an environment that facilitates ‘host-guest’ interaction which is being exploited in this study. Our research focuses on strategically synthesizing small heterocyclic compounds that are adaptable or compatible to drug ‘carriers/transporters’ to get them to their target sites. The study involves using microwave assisted click chemistry to synthesize triazole compounds and utilizing non-micelles having polar and non-polar compartment to encapsulate them. A photophysical study was carried out by using steady state fluorescence spectroscopy to evaluate the changes experienced by our triazole derivatives while interacting with the different components within the micellar environment and share in this conference.
