Synthesis of heterocyclic bis-amides derivatives through four-component condensation Ugi reaction.
Location
Poster Session 1 (Henderson Library)
Session Format
Poster Presentation
Your Campus
Statesboro Campus- Henderson Library, April 20th
Academic Unit
Department of Chemistry
Research Area Topic:
Natural & Physical Sciences - Chemistry
Abstract
This project focuses on a multicomponent reaction, Ugi; which is a four-component condensation reaction. Each of these reactions will utilize an aldehyde or ketone moiety, an amine, an isonitrile, and a carboxylic acid resulting in derivatives of bis-amides. In this project, we will target various derivatives of heterocyclic aromatic aldehydes to synthesize biologically active Ugi derivatives. Previous research has shown it to help with the treatment of illnesses like multiple myeloma, anti-malarial, anti-cancer, and antiproliferative treatments. All reactants will be successively (Aniline, an Aldehyde, Benzoic Acid, and Cyclohexylisocyanide) mixed together into a 10 mL microwave vial with a magnetic stirring bar. The mixture will be heated at 45℃ for 30 minutes at a power of 200W. Our hypothesis is not only we will get good yields and a faster rate of reaction, but the cleaning procedure will be very feasible because the final product results as a solid product that can be purified by the recrystallization procedure. The completion of the reaction will be monitored by Thin Layer Chromatography (TLC) and can be characterized by NMR (Nuclear Magnetic Resonance Spectroscopy) and Melting Point. The major goal of synthesizing this material is not only providing a novel methodology to the research community but also utilizing the derivatives to test as anti-cancer drugs in-vitro and in-vitro studies.
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
Presentation Type and Release Option
Presentation (Open Access)
Start Date
4-20-2022 10:00 AM
End Date
4-20-2022 11:30 AM
Recommended Citation
Gainey, Kiera L., "Synthesis of heterocyclic bis-amides derivatives through four-component condensation Ugi reaction." (2022). GS4 Georgia Southern Student Scholars Symposium. 12.
https://digitalcommons.georgiasouthern.edu/research_symposium/2022/2022/12
Synthesis of heterocyclic bis-amides derivatives through four-component condensation Ugi reaction.
Poster Session 1 (Henderson Library)
This project focuses on a multicomponent reaction, Ugi; which is a four-component condensation reaction. Each of these reactions will utilize an aldehyde or ketone moiety, an amine, an isonitrile, and a carboxylic acid resulting in derivatives of bis-amides. In this project, we will target various derivatives of heterocyclic aromatic aldehydes to synthesize biologically active Ugi derivatives. Previous research has shown it to help with the treatment of illnesses like multiple myeloma, anti-malarial, anti-cancer, and antiproliferative treatments. All reactants will be successively (Aniline, an Aldehyde, Benzoic Acid, and Cyclohexylisocyanide) mixed together into a 10 mL microwave vial with a magnetic stirring bar. The mixture will be heated at 45℃ for 30 minutes at a power of 200W. Our hypothesis is not only we will get good yields and a faster rate of reaction, but the cleaning procedure will be very feasible because the final product results as a solid product that can be purified by the recrystallization procedure. The completion of the reaction will be monitored by Thin Layer Chromatography (TLC) and can be characterized by NMR (Nuclear Magnetic Resonance Spectroscopy) and Melting Point. The major goal of synthesizing this material is not only providing a novel methodology to the research community but also utilizing the derivatives to test as anti-cancer drugs in-vitro and in-vitro studies.
