Exploring the biological relevance of a synthesized heterocyclic compounds in a model biomimetic
Location
Poster Session 1 (Henderson Library)
Session Format
Poster Presentation
Your Campus
Statesboro Campus- Henderson Library, April 20th
Academic Unit
Department of Chemistry
Research Area Topic:
Natural & Physical Sciences - Chemistry
Co-Presenters and Faculty Mentors or Advisors
Dr. Shainaz Landge
Dr. Debanjana Ghosh
Abstract
Biomembranes represents vital components of a biological systems. They are dynamical supramolecular structures made up of biomolecules such as lipids and proteins whose nanostructures are assembled in an organized manner to allow them to regulate some physiological processes. The well-defined ‘structure’ is strongly responsible for the varieties of biological ‘functions’ they perform. They serve as natural boundary between cells, specifically to distinguish the inner components from outer environment. The interactions between biomembranes and various bioactive molecules play an important role in many biological processes, including molecular recognition, signal transfer etc. Investigation of these processes requires the use of artificial model membranes. surfactants are amphiphilic molecules (hydrophobic and hydrophilic parts) which can form self-assemblies (micelles) in aqueous media. The packaging of surfactant molecules into closed structural network leads to the formation of extended bilayers that mimics the properties of a biomembrane and can help predict behavior of a drug in a biological environment. In general, our study utilized microwave-assisted click chemistry to synthesize triazole based molecules and uses the Nuclear Magnetic Resonance (NMR) to characterize synthesized compounds. Due to the fluorescent nature of the hydroxyaromatic-1,2,3-triazoyl molecules we used steady state fluorescence spectroscopy to examine their interaction within non-ionic micelles and quantify the approximate position of the triazole molecule within the micelles
Program Description
GEORGIA SOUTHERN UNIVERSITY RESEARCH SYMPOSIUM
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
Presentation Type and Release Option
Presentation (Open Access)
Start Date
4-20-2022 10:00 AM
End Date
4-20-2022 11:30 AM
Recommended Citation
Fasusi, Emmanuel T., "Exploring the biological relevance of a synthesized heterocyclic compounds in a model biomimetic" (2022). GS4 Georgia Southern Student Scholars Symposium. 11.
https://digitalcommons.georgiasouthern.edu/research_symposium/2022/2022/11
Exploring the biological relevance of a synthesized heterocyclic compounds in a model biomimetic
Poster Session 1 (Henderson Library)
Biomembranes represents vital components of a biological systems. They are dynamical supramolecular structures made up of biomolecules such as lipids and proteins whose nanostructures are assembled in an organized manner to allow them to regulate some physiological processes. The well-defined ‘structure’ is strongly responsible for the varieties of biological ‘functions’ they perform. They serve as natural boundary between cells, specifically to distinguish the inner components from outer environment. The interactions between biomembranes and various bioactive molecules play an important role in many biological processes, including molecular recognition, signal transfer etc. Investigation of these processes requires the use of artificial model membranes. surfactants are amphiphilic molecules (hydrophobic and hydrophilic parts) which can form self-assemblies (micelles) in aqueous media. The packaging of surfactant molecules into closed structural network leads to the formation of extended bilayers that mimics the properties of a biomembrane and can help predict behavior of a drug in a biological environment. In general, our study utilized microwave-assisted click chemistry to synthesize triazole based molecules and uses the Nuclear Magnetic Resonance (NMR) to characterize synthesized compounds. Due to the fluorescent nature of the hydroxyaromatic-1,2,3-triazoyl molecules we used steady state fluorescence spectroscopy to examine their interaction within non-ionic micelles and quantify the approximate position of the triazole molecule within the micelles
