Evaluation of Stereochemistry on Absorptivity and Depletion Activity of Protonated Tetraphenyl Porphyrins
Location
Poster Session 1 (Henderson Library)
Session Format
Poster Presentation
Your Campus
Statesboro Campus- Henderson Library, April 20th
Academic Unit
Department of Chemistry
Research Area Topic:
Natural & Physical Sciences - Chemistry
Co-Presenters and Faculty Mentors or Advisors
James M. LoBue
Abstract
Photodynamic therapy is a kind of treatment for various types of cancers that involves the use of a photosensitizer which works to kill tumor cells by producing singlet oxygen species when activated by light of a specific wavelength. The photosensitizing molecules examined for this research experiment were 3-Chloro Tetraphenyl Porphyrin (3-Cl TPP) and 4-Chloro Tetraphenyl Porphyrin (4-Cl TPP). From previous research studies performed, it was determined that a longer wavelength of light, 670nm versus 514nm, produced more significant readings for absorption and depletion activities of porphyrin photosensitizers at low pH levels. The absorptivity and depletion abilities were compared for the protonated states of these two porphyrin molecules by photolysis to determine whether the stereochemistry of each porphyrin molecule influenced its absorptivity and depletion ability for 9, 10-Diphenylanthracene (9, 10-DPA).
Program Description
The photochemical properties of two derivatives of tetraphenyl porphyrin were examined by laser photolysis in solution. Results have a bearing on the use of these derivatives in photodynamic therapy.
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
Presentation Type and Release Option
Presentation (Restricted to Georgia Southern)
Start Date
4-20-2022 10:00 AM
End Date
4-20-2022 11:30 AM
Recommended Citation
Andoh, Milcah A. and LoBue, James M., "Evaluation of Stereochemistry on Absorptivity and Depletion Activity of Protonated Tetraphenyl Porphyrins" (2022). GS4 Georgia Southern Student Scholars Symposium. 10.
https://digitalcommons.georgiasouthern.edu/research_symposium/2022/2022/10
Evaluation of Stereochemistry on Absorptivity and Depletion Activity of Protonated Tetraphenyl Porphyrins
Poster Session 1 (Henderson Library)
Photodynamic therapy is a kind of treatment for various types of cancers that involves the use of a photosensitizer which works to kill tumor cells by producing singlet oxygen species when activated by light of a specific wavelength. The photosensitizing molecules examined for this research experiment were 3-Chloro Tetraphenyl Porphyrin (3-Cl TPP) and 4-Chloro Tetraphenyl Porphyrin (4-Cl TPP). From previous research studies performed, it was determined that a longer wavelength of light, 670nm versus 514nm, produced more significant readings for absorption and depletion activities of porphyrin photosensitizers at low pH levels. The absorptivity and depletion abilities were compared for the protonated states of these two porphyrin molecules by photolysis to determine whether the stereochemistry of each porphyrin molecule influenced its absorptivity and depletion ability for 9, 10-Diphenylanthracene (9, 10-DPA).
