Self-assembled Silica Nanoparticles for Controlled Drug Delivery
Location
College of Science and Mathematics (COSM)
Session Format
Oral Presentation
Co-Presenters and Faculty Mentors or Advisors
Dr. Ji Wu, Faculty Advisor
Abstract
Due to the several limitations of conventional drug delivery systems, controlled drug delivery is needed to improve therapeutic efficacy of medications in the treatment of chronical diseases. One of the ways to achieve controlled drug delivery is by incorporating drug molecules into nanoparticles. Silica nanoparticles have been shown to be safe, biocompatible and have suitable drug loading capabilities. Our research is focused on achieving controlled drug release by incorporating organic drug molecules like ibuprofen and nicotine into the interstices of self-assembled silica nanoparticles through hydrogen bonding at a specific pH and releasing drug molecules at another pH by breaking as-formed hydrogen bonding. Scanning Electron Microscope (SEM), Dynamic Light Scattering (DLS), Raman Spectroscopy, UV-Vis absorption spectroscopy are employed to investigate the size, morphology, zeta potential of the silica nanoparticles and the incorporation of ibuprofen into the silica nanoparticle assembly. Parameters such as pH and mass ratio between silica particles and ibuprofen are varied to study their effect on the self-assembly of silica nanoparticles and rate of drug delivery. Low pH was found to improve self-assembly of silica nanoparticles. Lastly, drug delivery rate is quantified by using High Performance Liquid Chromatography (HPLC) attached with a UV-Vis detector.
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
Presentation Type and Release Option
Presentation (Open Access)
Recommended Citation
Femi-Oyetoro, Charity, "Self-assembled Silica Nanoparticles for Controlled Drug Delivery" (2021). GS4 Georgia Southern Student Scholars Symposium. 56.
https://digitalcommons.georgiasouthern.edu/research_symposium/2021/2021/56
Self-assembled Silica Nanoparticles for Controlled Drug Delivery
College of Science and Mathematics (COSM)
Due to the several limitations of conventional drug delivery systems, controlled drug delivery is needed to improve therapeutic efficacy of medications in the treatment of chronical diseases. One of the ways to achieve controlled drug delivery is by incorporating drug molecules into nanoparticles. Silica nanoparticles have been shown to be safe, biocompatible and have suitable drug loading capabilities. Our research is focused on achieving controlled drug release by incorporating organic drug molecules like ibuprofen and nicotine into the interstices of self-assembled silica nanoparticles through hydrogen bonding at a specific pH and releasing drug molecules at another pH by breaking as-formed hydrogen bonding. Scanning Electron Microscope (SEM), Dynamic Light Scattering (DLS), Raman Spectroscopy, UV-Vis absorption spectroscopy are employed to investigate the size, morphology, zeta potential of the silica nanoparticles and the incorporation of ibuprofen into the silica nanoparticle assembly. Parameters such as pH and mass ratio between silica particles and ibuprofen are varied to study their effect on the self-assembly of silica nanoparticles and rate of drug delivery. Low pH was found to improve self-assembly of silica nanoparticles. Lastly, drug delivery rate is quantified by using High Performance Liquid Chromatography (HPLC) attached with a UV-Vis detector.
