Assessing the Aptitude of Ionic Current Rectification in Developing Controllable Drug Delivery Systems: A Survey Using Ibuprofen
Location
College of Science and Mathematics (COSM)
Session Format
Oral Presentation
Co-Presenters and Faculty Mentors or Advisors
Dr. Ji Wu
Abstract
Within the sphere of clinical research, the provisional healthcare applications of nanoparticles have seen an emphasis in the past decade on account of their realized potential in translational medicine. Integration of nanomedicine into primary care has incited increased efficiency in the conduction of patient treatment, particularly in a time where patient convenience and post-visit care maintenance have become an apt agenda in universal healthcare delivery. The principle of applying ionic current rectification through nanoporous material, has proven plausible in the development of controllable drug delivery systems, as evidenced by previous findings of this ongoing project. However, we now turn our sights to realizing applications of ionic current rectification in biomedical nanotechnology, making further insight into its potential pertinent. In this report, the aptitude for formulating an efficient and easily controlled delivery system was assessed through utilization of ionic current rectification methods of continuous diffusion in unison with the drug ibuprofen, a commonly prescribed pain reliever. In testing this potential, silica nanoparticles synthesized with a negative and positive surface charge were incorporated with differing concentrations of ibuprofen and used to demonstrate the utility of ionic rectification in controlling the flow of a commercially prevalent drug molecule through nanoparticle-regulated nanoporous apertures. With this, the prospective efficacy of ionic rectification in such drug trials would act to support its use in the formulation of amenable drug delivery systems for not solely ibuprofen, but many other viable drug candidates that are frequently regimented.
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
Presentation Type and Release Option
Presentation (Open Access)
Recommended Citation
Mitchell, Juan, "Assessing the Aptitude of Ionic Current Rectification in Developing Controllable Drug Delivery Systems: A Survey Using Ibuprofen" (2021). GS4 Georgia Southern Student Scholars Symposium. 48.
https://digitalcommons.georgiasouthern.edu/research_symposium/2021/2021/48
Assessing the Aptitude of Ionic Current Rectification in Developing Controllable Drug Delivery Systems: A Survey Using Ibuprofen
College of Science and Mathematics (COSM)
Within the sphere of clinical research, the provisional healthcare applications of nanoparticles have seen an emphasis in the past decade on account of their realized potential in translational medicine. Integration of nanomedicine into primary care has incited increased efficiency in the conduction of patient treatment, particularly in a time where patient convenience and post-visit care maintenance have become an apt agenda in universal healthcare delivery. The principle of applying ionic current rectification through nanoporous material, has proven plausible in the development of controllable drug delivery systems, as evidenced by previous findings of this ongoing project. However, we now turn our sights to realizing applications of ionic current rectification in biomedical nanotechnology, making further insight into its potential pertinent. In this report, the aptitude for formulating an efficient and easily controlled delivery system was assessed through utilization of ionic current rectification methods of continuous diffusion in unison with the drug ibuprofen, a commonly prescribed pain reliever. In testing this potential, silica nanoparticles synthesized with a negative and positive surface charge were incorporated with differing concentrations of ibuprofen and used to demonstrate the utility of ionic rectification in controlling the flow of a commercially prevalent drug molecule through nanoparticle-regulated nanoporous apertures. With this, the prospective efficacy of ionic rectification in such drug trials would act to support its use in the formulation of amenable drug delivery systems for not solely ibuprofen, but many other viable drug candidates that are frequently regimented.
