The Role of Social Determinants of Health in Hydroxyurea Adherence Among Persons with Sickle Cell Disease: A Systematic Review
Location
Jiann-Ping Hsu College of Public Health (JPHCOPH)
Session Format
Oral Presentation
Co-Presenters and Faculty Mentors or Advisors
Dr. Tilicia L. Mayo-Gamble, Faculty Advisor
Abstract
Medication adherence in sickle cell disease (SCD) is associated with important clinical outcomes and social determinants of health (SDoH). This systematic literature review synthesized the literature on SDoH addressed in studies to improve hydroxyurea adherence in persons with SCD. SDoH that were identified have not been described in previous literature. SDoH were based on the five categories defined in Healthy People 2020. Twelve studies were selected and assessed for this systematic literature review using online databases. Four out of five categories of SDoH were highlighted in studies addressing hydroxyurea adherence. SDoH were divided between barriers versus facilitators. We found that health and healthcare access (i.e., access to care, health literacy) was the SDoH most reported as a barrier to hydroxyurea adherence. Social and community context (e.g., peer support, community health worker, and patient navigator) was the most common facilitator to hydroxyurea adherence. Our analysis highlights a gap in the literature related to education as a SDoH and its relationship to hydroxyurea adherence among persons with SCD. Social determinants of health are a challenge for clinicians to address. Future research should explore development of multilevel interventions that address social determinants of health to improve hydroxyurea adherence in African Americans with SCD.
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
Presentation Type and Release Option
Presentation (Open Access)
Recommended Citation
Kayode, Ifeoluwa, "The Role of Social Determinants of Health in Hydroxyurea Adherence Among Persons with Sickle Cell Disease: A Systematic Review" (2021). GS4 Georgia Southern Student Scholars Symposium. 29.
https://digitalcommons.georgiasouthern.edu/research_symposium/2021/2021/29
The Role of Social Determinants of Health in Hydroxyurea Adherence Among Persons with Sickle Cell Disease: A Systematic Review
Jiann-Ping Hsu College of Public Health (JPHCOPH)
Medication adherence in sickle cell disease (SCD) is associated with important clinical outcomes and social determinants of health (SDoH). This systematic literature review synthesized the literature on SDoH addressed in studies to improve hydroxyurea adherence in persons with SCD. SDoH that were identified have not been described in previous literature. SDoH were based on the five categories defined in Healthy People 2020. Twelve studies were selected and assessed for this systematic literature review using online databases. Four out of five categories of SDoH were highlighted in studies addressing hydroxyurea adherence. SDoH were divided between barriers versus facilitators. We found that health and healthcare access (i.e., access to care, health literacy) was the SDoH most reported as a barrier to hydroxyurea adherence. Social and community context (e.g., peer support, community health worker, and patient navigator) was the most common facilitator to hydroxyurea adherence. Our analysis highlights a gap in the literature related to education as a SDoH and its relationship to hydroxyurea adherence among persons with SCD. Social determinants of health are a challenge for clinicians to address. Future research should explore development of multilevel interventions that address social determinants of health to improve hydroxyurea adherence in African Americans with SCD.