Presentation Title

Total Synthesis of Herbarin A and B and Determination of Antioxidant Properties and Toxicity in Zebra Fish Model

Location

Atrium

Session Format

Poster Presentation

Research Area Topic:

Natural & Physical Sciences - Chemistry

Roundtable Presentation Participants

NA

Co-Presenters, Co- Authors, Co-Researchers, Mentors, or Faculty Advisors

Hannah C. Cade

Jihan Padgett

Dr. Vinoth Sittaramane

Dr. Laxman Pandey

Dr. Abid Shaikh

Abstract

Herbarin A and B were from two strains of the fungus Cladosporium herbarum found in sponges Aplysina aerophoba and Callyspongia aerizusa, respectively. Initial biological activity of these natural products was performed on polyphagous pest insect larvae and brine shrimp larvae. As a consequence of their remarkable biological activity and unique chemical structure, we describe a multi-step synthetic route towards Herbarin A and B. This synthetic approach provided target compounds in multi-gram scale quantity, which is not possible from their natural source. Antioxidant properties of Herbarin A and B were investigated and toxicity of these compounds was determined using a zebrafish embryo model.

Keywords

Total synthesis, Antioxidant properties, Natural products, Toxicity, Zebrafish

Presentation Type and Release Option

Presentation (Open Access)

Start Date

4-24-2015 2:45 PM

End Date

4-24-2015 4:00 PM

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Apr 24th, 2:45 PM Apr 24th, 4:00 PM

Total Synthesis of Herbarin A and B and Determination of Antioxidant Properties and Toxicity in Zebra Fish Model

Atrium

Herbarin A and B were from two strains of the fungus Cladosporium herbarum found in sponges Aplysina aerophoba and Callyspongia aerizusa, respectively. Initial biological activity of these natural products was performed on polyphagous pest insect larvae and brine shrimp larvae. As a consequence of their remarkable biological activity and unique chemical structure, we describe a multi-step synthetic route towards Herbarin A and B. This synthetic approach provided target compounds in multi-gram scale quantity, which is not possible from their natural source. Antioxidant properties of Herbarin A and B were investigated and toxicity of these compounds was determined using a zebrafish embryo model.