Total Synthesis of Herbarin A and B and Determination of Antioxidant Properties and Toxicity in Zebra Fish Model
Location
Atrium
Session Format
Poster Presentation
Research Area Topic:
Natural & Physical Sciences - Chemistry
Roundtable Presentation Participants
NA
Co-Presenters and Faculty Mentors or Advisors
Hannah C. Cade
Jihan Padgett
Dr. Vinoth Sittaramane
Dr. Laxman Pandey
Dr. Abid Shaikh
Abstract
Herbarin A and B were from two strains of the fungus Cladosporium herbarum found in sponges Aplysina aerophoba and Callyspongia aerizusa, respectively. Initial biological activity of these natural products was performed on polyphagous pest insect larvae and brine shrimp larvae. As a consequence of their remarkable biological activity and unique chemical structure, we describe a multi-step synthetic route towards Herbarin A and B. This synthetic approach provided target compounds in multi-gram scale quantity, which is not possible from their natural source. Antioxidant properties of Herbarin A and B were investigated and toxicity of these compounds was determined using a zebrafish embryo model.
Keywords
Total synthesis, Antioxidant properties, Natural products, Toxicity, Zebrafish
Presentation Type and Release Option
Presentation (Open Access)
Start Date
4-24-2015 2:45 PM
End Date
4-24-2015 4:00 PM
Recommended Citation
Heimberger, Julia Anne, "Total Synthesis of Herbarin A and B and Determination of Antioxidant Properties and Toxicity in Zebra Fish Model" (2015). GS4 Georgia Southern Student Scholars Symposium. 96.
https://digitalcommons.georgiasouthern.edu/research_symposium/2015/2015/96
Total Synthesis of Herbarin A and B and Determination of Antioxidant Properties and Toxicity in Zebra Fish Model
Atrium
Herbarin A and B were from two strains of the fungus Cladosporium herbarum found in sponges Aplysina aerophoba and Callyspongia aerizusa, respectively. Initial biological activity of these natural products was performed on polyphagous pest insect larvae and brine shrimp larvae. As a consequence of their remarkable biological activity and unique chemical structure, we describe a multi-step synthetic route towards Herbarin A and B. This synthetic approach provided target compounds in multi-gram scale quantity, which is not possible from their natural source. Antioxidant properties of Herbarin A and B were investigated and toxicity of these compounds was determined using a zebrafish embryo model.
