Honors College Theses
Publication Date
5-6-2022
Major
Biochemistry (B.S.)
Release Option
Open Access
Faculty Mentor
Nathaniel Shank
Abstract
Peptide nucleic acids (PNAs) are oligonucleotide analogues in which the sugar-phosphate backbone has been replaced by a pseudopeptide skeleton. Since PNAs use the natural nucleobases (Adenine, Thymine, Cytosine, Uracil, and Guanine) found in either DNA and/or RNA, they are able to hybridize according to Watson-Crick base-pairing to form duplexes. PNA is a promising therapeutic agent because they can function as antigene or antisense chemical agents. To further enhance their utility, we aim to incorporate a photoswitchable moiety using azobenzene. Here, we report the results of the synthesis and purification of a photoswitchable 11 mer PNA along with initial characterization efforts.
Copyright
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Recommended Citation
Nguyen, Kat, "Analysis of the Light Responsive Azobenzene Peptide Nucleic Acid Duplexes" (2022). Honors College Theses. 765.
https://digitalcommons.georgiasouthern.edu/honors-theses/765
Included in
Analytical Chemistry Commons, Biochemistry Commons, Inorganic Chemistry Commons, Materials Chemistry Commons, Organic Chemistry Commons, Physical Chemistry Commons, Polymer Chemistry Commons
