Honors College Theses

Publication Date

4-30-2021

Major

Chemistry (B.S.)

Document Type and Release Option

Thesis (restricted to Georgia Southern)

Faculty Mentor

Ji Wu

Abstract

Usage of nanoparticles in current medicine has been continuously practiced creating an effective delivery system for various drugs. Through the practice of nanomedicine in healthcare today, it has been found to be an efficient process in treatments. Within this project, a novel ionic rectification method is employed to control the delivery rates of nicotine for an effective smoking cessation treatment. The ionic rectification was accomplished by blocking and opening the pores of nanoporous membranes using an external electrical field and functionalized silica nanoparticles. In this project, we systematically studied the effects of current, voltage, ionic strength, pore size and pH on the ionic rectification and controllability of nicotine delivery. The delivery rates of nicotine through the ionic rectification system were accurately determined using a high-performance liquid chromatography combined with UV-Vis detector. Future results will provide an insightful guidance for the development of the next generation drug delivery platforms with high efficiency, versatility, controllability, and low fabrication cost.

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Available for download on Wednesday, April 29, 2026

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