The Balance of Apoptosis and Autophagy via Regulation of the AMPK Signal Pathway in Aging Rat Striatum During Regular Aerobic Exercise

Authors

Wenfeng Liu, Hunan Normal UniversityFollow
Zhiyuan Wang, Hunan Normal University
Yan Xia, Hunan Normal UniversityFollow
Heyu Kuang, Hunan Normal UniversityFollow
Shaopeng Liu, Hunan Normal UniversityFollow
Li Li, Georgia Southern UniversityFollow
Changfa Tang, Hunan Normal UniversityFollow
Dazhong Yin, Hunan Normal UniversityFollow

Document Type

Article

Publication Date

6-27-2019

Publication Title

Experimental Gerontology

DOI

10.1016/j.exger.2019.110647

ISSN

0531-5565

Abstract

The objective was to analyze the effects of aerobic exercise on aging striatum stress resistance, and the adaptive mechanisms related to neurodegenerative diseases, and the occurrence, and development of neural degeneration. The 10-weeks of regular moderate-intensity aerobic exercise intervention were carried out in the aerobic exercise runner Sprague-Dawley rats. Apoptotic nuclei appeared in the striatum of aged rats, showing a tendency to relate to aging. The apoptotic index of the striatum in young, middle-aged, and old-aged rats of the aerobic exercise groups increased by 205.56%, 57%, and 68.24%. Autophagy markers Beclin l and LC 3-II expression, AMPKα1 and pAMPKα1 expression increased significantly in all age-exercise groups. The ratio of AMPKα1/pAMPKα1 increased after exercise, and the tendency of exercise to alter autophagy and cell apoptosis increased with aging. Then SirT2 mRNA was significantly upregulated in the aerobic exercise runner groups. In conclusion, we showed that the balance of autophagy and apoptosis were closely regulated by regular aerobic exercise, which affected the development of aging, and via regulation of the AMPK/SirT2 signaling pathway.

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Recommended Citation

Liu, Wenfeng, Zhiyuan Wang, Yan Xia, Heyu Kuang, Shaopeng Liu, Li Li, Changfa Tang, Dazhong Yin. 2019. "The Balance of Apoptosis and Autophagy via Regulation of the AMPK Signal Pathway in Aging Rat Striatum During Regular Aerobic Exercise." Experimental Gerontology, 124: Elsevier. doi: 10.1016/j.exger.2019.110647 source: 10.1016/j.exger.2019.110647
https://digitalcommons.georgiasouthern.edu/health-kinesiology-facpubs/174