Term of Award

Summer 2012

Degree Name

Doctor of Public Health in Biostatistics (Dr.P.H.)

Document Type and Release Option

Dissertation (restricted to Georgia Southern)

Copyright Statement / License for Reuse

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.

Department

Department of Biostatistics (COPH)

Committee Chair

Karl Peace

Committee Member 1

Broderick Oluyede

Committee Member 2

Lili Yu

Committee Member 3

Kao-Tai Tsai

Abstract

Covariates on subjects are collected in addition to times-to-event in time-to-event studies. Such data are often analyzed by choosing a model that allows the covariate information to be utilized in the analyses. The analysis proceeds by estimating parameters in the model and testing hypotheses about the parameters based on their estimates; validity of inferences from tests of hypotheses about the parameters depends on size and power of the tests. The Lindley model is considered, in this dissertation, as an alternative model facilitating the analysis of time-to-event data with or without covariates for complete or incomplete data. Covariate information is incorporated using the form of Cox's proportional hazard's model with the Lindley model as the time dependent component (called Lindley-Cox model). Results suggest that size of tests on parameters arising from their maximum likelihood estimates (MLEs) in the Lindley-Cox model is -level and power of tests on parameters arising from their MLEs in this model compares to that from MLEs in Cox's.

Research Data and Supplementary Material

No

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