Term of Award

Summer 2025

Degree Name

Master of Science, Mechanical Engineering

Document Type and Release Option

Thesis (open access)

Copyright Statement / License for Reuse

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.

Department

Department of Mechanical Engineering

Committee Chair

Mujibur Khan

Committee Member 1

Mohammadamin Ezazi

Committee Member 2

Hayeri Sezer

Abstract

Electro-spraying has been used as an effective processing method of nanoparticle fabrication for the application of targeted drug delivery. The study demonstrates the feasibility of a non-conventional triaxial electro-spraying setup for multi-layered nano-drug fabrication and proposes optimized parameters. Two different drugs, XAV939 and Dextran 40000, were used to study the process parameters (voltage and solution concentration) of coaxial electro spraying. The particle size of Dextran-PCL was an average of 166.3 nm for PCL-Dextran at 32.5 kV and 18-hour sonication. The SEM analysis and UV-spectrum showed the encapsulation of Dextran with PCL, though the in vitro study in mice after 24 hrs. showed the particles had not reached to lungs and spleen.

Two triaxial configurations were developed using GW2850, Dextran 40000 in different combinations as core material with PCL and CD13-targeting peptide as the third layer: (1) Dextran core with GW2850 and PCL shells, and (2) GW2850 core encapsulated by PCL and NGR CD13-peptide. UV-Vis and FTIR analysis confirmed the presence of each drug component in the final particles, indicating successful encapsulation. longer PCL sonication time and high voltages between 41KV to 45KV resulted in spherical particles, while inadequate processing led to fibrous structures or agglomerates. Concentration of NGR Peptide above 0.9 mg/ml also showed fibrous structures in SEM.

OCLC Number

1528848929

Research Data and Supplementary Material

Yes

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