Term of Award
Master of Science, Applied Physical Science
Document Type and Release Option
Thesis (open access)
Copyright Statement / License for Reuse
This work is licensed under a Creative Commons Attribution 4.0 License.
Department of Chemistry and Biochemistry
Committee Member 1
Committee Member 2
The lack of approved vaccines, medications and treatment regimens has significantly contributed to the rapid spread of mosquito-borne viruses such as Dengue and Zika virus. The complex immunopathology of these viruses presents limitations for the development and implementation of a definitive, safe and effective approach to combat infections.Previous research has demonstrated that vector control strategies such as the elimination of larval habitats, larviciding with insecticides, the use of biological agents and the application of adulticides have been unsuccessful in the reduction of viral transmission leading to the need for the continued development of antivirals. This research proposes an approach for a drug delivery system that involves novel antivirals that suppress dengue virus in an intracellular pH specific manner with the use of micellar nanoparticles. Drug-loaded nanoparticle that dissociates when exposed to a pH of 6.0, will release drug at the targeted location in the cell, in particular, the proximal trans-Golgi network in the cell. Three (3) novel pyridazine derivatives were analyzed and possessed anti-viral activity against Zika virus through the use of cell-culture based suppression techniques. The derivatives described in this thesis will be designed and analyzed for its future potential in drug encapsulation into newly synthesized mPEG-PLA comprised micellar nanoparticles.
Culmer, Janae A., "Development of Novel Pyridazine Derivatives and Drug Delivery Systems Against Dengue" (2022). Electronic Theses and Dissertations. 2501.
Research Data and Supplementary Material