Term of Award

Fall 2022

Degree Name

Master of Science, Applied Physical Science

Document Type and Release Option

Thesis (open access)

Copyright Statement / License for Reuse

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.

Department

Department of Chemistry and Biochemistry

Committee Chair

James Carter

Committee Member 1

Debanjana Ghosh

Committee Member 2

Christine Whitlock

Abstract

The lack of approved vaccines, medications and treatment regimens has significantly contributed to the rapid spread of mosquito-borne viruses such as Dengue and Zika virus. The complex immunopathology of these viruses presents limitations for the development and implementation of a definitive, safe and effective approach to combat infections.Previous research has demonstrated that vector control strategies such as the elimination of larval habitats, larviciding with insecticides, the use of biological agents and the application of adulticides have been unsuccessful in the reduction of viral transmission leading to the need for the continued development of antivirals. This research proposes an approach for a drug delivery system that involves novel antivirals that suppress dengue virus in an intracellular pH specific manner with the use of micellar nanoparticles. Drug-loaded nanoparticle that dissociates when exposed to a pH of 6.0, will release drug at the targeted location in the cell, in particular, the proximal trans-Golgi network in the cell. Three (3) novel pyridazine derivatives were analyzed and possessed anti-viral activity against Zika virus through the use of cell-culture based suppression techniques. The derivatives described in this thesis will be designed and analyzed for its future potential in drug encapsulation into newly synthesized mPEG-PLA comprised micellar nanoparticles.

OCLC Number

1360439178

Research Data and Supplementary Material

No

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