Term of Award

Spring 2021

Degree Name

Master of Science in Applied Physical Science (M.S.)

Document Type and Release Option

Thesis (restricted to Georgia Southern)

Copyright Statement / License for Reuse

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.

Department

Department of Physics and Astronomy

Committee Chair

Dragos Amarie

Committee Member 1

Hau-Jian Liu

Committee Member 2

Ionut Emil Iacob

Abstract

Chemotaxis is a phenomenon driven largely by chemical gradients, therefore by emulating the biophysical environment of cells, we can understand and manipulate chemical gradients in order to study the cells. In this study, four devices generating nonlinear chemical gradients and one generating a linear chemical gradient were designed. Each of the devices is designed to mix two fluids of different concentration by diffusion, passing through a series of bifurcated and trifurcated microchannels and mixers which split and recombine flows in the gradient generating section of the device. Unlike the linear structure, a bias was introduced in the mixers of the four other structures to generate the non-linear chemical gradients. The study entails the use of AutoCAD to draw designs and COMSOL simulation software to predict the fluid flow in the devices.

Research Data and Supplementary Material

Yes

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