Term of Award
Spring 2021
Degree Name
Master of Science in Applied Physical Science (M.S.)
Document Type and Release Option
Thesis (restricted to Georgia Southern)
Copyright Statement / License for Reuse
This work is licensed under a Creative Commons Attribution 4.0 License.
Department
Department of Physics and Astronomy
Committee Chair
Dragos Amarie
Committee Member 1
Hau-Jian Liu
Committee Member 2
Ionut Emil Iacob
Abstract
Chemotaxis is a phenomenon driven largely by chemical gradients, therefore by emulating the biophysical environment of cells, we can understand and manipulate chemical gradients in order to study the cells. In this study, four devices generating nonlinear chemical gradients and one generating a linear chemical gradient were designed. Each of the devices is designed to mix two fluids of different concentration by diffusion, passing through a series of bifurcated and trifurcated microchannels and mixers which split and recombine flows in the gradient generating section of the device. Unlike the linear structure, a bias was introduced in the mixers of the four other structures to generate the non-linear chemical gradients. The study entails the use of AutoCAD to draw designs and COMSOL simulation software to predict the fluid flow in the devices.
OCLC Number
1257555428
Catalog Permalink
https://galileo-georgiasouthern.primo.exlibrisgroup.com/permalink/01GALI_GASOUTH/1r4bu70/alma9916469249202950
Recommended Citation
Akinniyi, Oluwafemi Matthew, "Designing Microfluidic Devices To Produce Nonlinear Chemical Gradients" (2021). Electronic Theses and Dissertations. 2262.
https://digitalcommons.georgiasouthern.edu/etd/2262
Research Data and Supplementary Material
Yes
