Faculty Mentor
Dr. James R. Carter
Faculty Mentor Email
jrcarter@georgiasouthern.edu
Presentation Type and Release Option
Research Poster Presentation (Open Access)
Location
COUR Smyposium 2021
Presentation Year
2021
Start Date
4-19-2021 12:00 AM
End Date
4-19-2021 12:00 AM
Abstract
Biocompatible micellar nanoparticles provide a platform to increase drug solubility, increasing cellular uptake, and leading to increased control of virus infection We are interested in the utility of pH responsive nanoparticles possessing the ability to deliver drug cargo intracellularly, in a pH dependent manner, coupled with known and novel antiviral compounds The presented research describes the assembly and characterization of mPEG PAE methoxy polyethylene glycol PEG Poly(β amino ester) micelles These micelles have been designed and synthesized to possess the ability to disassemble at pH 6 0 the pH of the trans Golgi this will result in the release of encapsulated drug cargo, and presumably lead to failure of virus proteins to add complex sugars to high mannose chains and subsequent decrease in virus particle assembly and suppression of virus replication Described in this poster is the synthesis of mPEG PAE polymers and experiments leading to micellar formation of these polymers and biophysical characterization following encapsulation of with ribavirin, a broad spectrum antiviral Results show the proper formation and characterization of ribavirin encapsulated mPEG PAE micellar nanoparticles and give promise to their use in suppression of virus infection
Included in
Synthesis and Characterization of Diblock, pH Responsive Drug Delivery mPEG Poly(β amino ester) Polymeric Micelles
COUR Smyposium 2021
Biocompatible micellar nanoparticles provide a platform to increase drug solubility, increasing cellular uptake, and leading to increased control of virus infection We are interested in the utility of pH responsive nanoparticles possessing the ability to deliver drug cargo intracellularly, in a pH dependent manner, coupled with known and novel antiviral compounds The presented research describes the assembly and characterization of mPEG PAE methoxy polyethylene glycol PEG Poly(β amino ester) micelles These micelles have been designed and synthesized to possess the ability to disassemble at pH 6 0 the pH of the trans Golgi this will result in the release of encapsulated drug cargo, and presumably lead to failure of virus proteins to add complex sugars to high mannose chains and subsequent decrease in virus particle assembly and suppression of virus replication Described in this poster is the synthesis of mPEG PAE polymers and experiments leading to micellar formation of these polymers and biophysical characterization following encapsulation of with ribavirin, a broad spectrum antiviral Results show the proper formation and characterization of ribavirin encapsulated mPEG PAE micellar nanoparticles and give promise to their use in suppression of virus infection
