Chemistry: Faculty Publications (1990-2023)
A Novel Synthesis of p-Nitrobenzylphosphonic Acid and Its Action on Alkaline Phosphatase
Document Type
Article
Publication Date
2008
Publication Title
Letters in Organic Chemistry
DOI
10.2174/157017808785982167
ISSN
1875-6255
Abstract
p-Nitrobenzylphosphonic acid was obtained via a nucleophilic substitution of nitrobenzyl bromide with trimethyl phosphite as opposed to nitration of benzylphosphonic acid. This compound is a competitive inhibitor of alkaline phosphatase (KI ∼ 125 μM) and has potential to inhibit a wide range of other phosphatases including serine/threonine phosphatases and tyrosine phosphatases.
Recommended Citation
Davis McGibony, C. Michele, Kevin J. Hand, R. Bryan Sears, Trianna R. McCall.
2008.
"A Novel Synthesis of p-Nitrobenzylphosphonic Acid and Its Action on Alkaline Phosphatase."
Letters in Organic Chemistry, 5 (7): 563-565: Bentham Science Publishers.
doi: 10.2174/157017808785982167 source: http://www.eurekaselect.com/83321/article
https://digitalcommons.georgiasouthern.edu/chem-facpubs/53
Copyright
This work is archived and distributed under the repository's Standard Copyright and Reuse License (opens in new tab). End users may copy, store, and distribute this work without restriction. For all other uses, permission must be obtained from the copyright owners or their authorized agents.
