Furanylidene Systems from a Tosylic Acid- Mediated, Tandem Desilylation-Cyclization Reaction of Silyl Ethers of Monoalkynylated Β -Keto Carbonyls
Document Type
Article
Publication Date
2011
Publication Title
Heterocyclic Communications
DOI
10.1515/HC.2011.044
ISSN
2191-0197
Abstract
Single isomers of the furanylidene system 8 were synthesized in four steps. The synthesis begins with the dianion of β-keto carbonyls and culminates in a mild, tandem desilylation-cyclization reaction using tosylic acid. Compounds synthesized in this study have the potential for further diversification at the alkyne, carbonyl and enol-ether moieties. Hence, the furanylidenes from this study are prospective building blocks for biologically active, furan-containing natural products and their analogs.
Recommended Citation
Oxford, John, Rayaj Ahamed, Morgan Hudson-Davis, Brandi Womack, Laura Gessner, Kristina Deveaux, Ebonni Fisher, Karelle Aiken.
2011.
"Furanylidene Systems from a Tosylic Acid- Mediated, Tandem Desilylation-Cyclization Reaction of Silyl Ethers of Monoalkynylated Β -Keto Carbonyls."
Heterocyclic Communications, 17 (5-6): 227-231: De Gruyter.
doi: 10.1515/HC.2011.044 source: https://www.degruyter.com/view/j/hc.2011.17.issue-5-6/hc.2011.044/hc.2011.044.xml
https://digitalcommons.georgiasouthern.edu/chem-facpubs/5
