Chemistry: Faculty Publications (1990-2023)
Lewis Acid-Catalyzed Csp3-H Functionalization of Methyl Azaarenes with α-Trifluoromethyl Carbonyl Compounds
Document Type
Article
Publication Date
2013
Publication Title
Tetrahedron Letters
DOI
10.1016/j.tetlet.2012.12.013
ISSN
0040-4039
Abstract
A Lewis acid promoted Csp3–H bond functionalization of methyl azaarenes with α-trifluoromethylated carbonyl compounds is described. Catalytic amounts of Yb(OTf)3 provided a straightforward access to the corresponding trifluoromethylated alcohols in excellent yields up to 94% under mild reaction conditions.
Recommended Citation
Graves, Vincent B., Abid Shaikh.
2013.
"Lewis Acid-Catalyzed Csp3-H Functionalization of Methyl Azaarenes with α-Trifluoromethyl Carbonyl Compounds."
Tetrahedron Letters, 54 (7): 695-698: Elsevier.
doi: 10.1016/j.tetlet.2012.12.013 source: https://www.sciencedirect.com/science/article/pii/S004040391202134X?via%3Dihub
https://digitalcommons.georgiasouthern.edu/chem-facpubs/33
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