Synthesis, Characterization, Computational Study, and Biological Relevance of a Family of Isostructural, Mononuclear Ln (Ln = Gd, Tb, Dy, Ho, Er) Complexes Containing Pyridoxine, an Essential Ingredient of Vitamin B6 Enzyme
Document Type
Article
Publication Date
8-1-2017
Publication Title
Inorganica Chimica Acta
DOI
10.1016/j.ica.2017.05.006
Abstract
The synthesis and characterization of a family of LnIII complexes (Ln = Gd(1), Tb(2), Dy(3), Ho(4) and Er(5)) of formula [(LnIII(NO3)2(OH2)(pyridoxine)2](NO3) are reported, where pyridoxine is 2-methyl-3-hydroxy-4,5-bis(hydroxymethyl)pyridine. They were obtained from the reaction of Ln(NO3)3 with pyridoxine in ethanol in a 1:1 M ratio. The crystal structures of representative 1 and 5 were obtained using a single-crystal X-ray diffractometer. The subsequent characterization of all the complexes was performed using elemental analysis, IR spectroscopy and UV–Vis spectroscopy. The gadolinium complex was further analyzed to determine if DNA is a biological target of this series of metal complexes. In this regard, the interaction between the gadolinium complex and DNA was probed utilizing circular dichroism spectroscopy. The study supports the moderate binding of complex 1 to DNA.
Recommended Citation
Stouder, Caitlyn E., Khairi J. Warren, Olivia F. Perdue, Amanda L. Stewart, Clifford W. Padgett, Allison J. Amonette, Arpita Saha.
2017.
"Synthesis, Characterization, Computational Study, and Biological Relevance of a Family of Isostructural, Mononuclear Ln (Ln = Gd, Tb, Dy, Ho, Er) Complexes Containing Pyridoxine, an Essential Ingredient of Vitamin B6 Enzyme."
Inorganica Chimica Acta, 464: 172-181: Elsevier.
doi: 10.1016/j.ica.2017.05.006 source: sciencedirect.com
https://digitalcommons.georgiasouthern.edu/chem-facpubs/140
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