Targeted Delivery of Drugs to Colon

Document Type

Contribution to Book

Publication Date

3-25-2016

Publication Title

Drug Delivery: Principles and Applications

DOI

10.1002/9781118833322.ch18

ISBN

978-1-1188-3332-2

Abstract

Colon‐targeted drug deliveries have become valuable and efficient drug delivery options. One factor to consider in specifically targeting the colon is the question of how well the colon can absorb different drugs. Prodrug techniques typically used to target the colon include microbially activated prodrugs, pH‐sensitive released prodrugs, osmotic‐controlled release prodrugs, and pressure‐controlled release prodrugs, which combine the former techniques with release from the colonic peristalsis and high viscosity, as well as novel formulations such as nanoparticles. Nanoparticle approaches can incorporate any of the colon‐targeting techniques, including release by colonic microflora metabolism, pH, and pressure. The use of colon cancer‐targeting nanoparticles has also been of interest. For example, the use of monoclonal antibody‐modified nanoparticles to target the colon was demonstrated in a study where cetuximab‐modified human serum albumin (HSA)‐nanoparticles were shown to differentially bind to and to accumulate in colon carcinoma cells.

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