Visualization of Mercury(II) Accumulation in Vivo Using Bioluminescence Imaging with a Highly Selective Probe

Authors

Bowen Ke, Sichuan University
Hui Chen, Sichuan University
Li Ma, Georgia Southern UniversityFollow
Sarah Zingales, Armstrong State UniversityFollow
Deying Gong, Sichuan University
Die Hu, Sichuan University
Lupei Du, Shandong University
Minyong Li, Shandong UniversityFollow

Document Type

Article

Publication Date

1-1-2018

Publication Title

Organic and Biomolecular Chemistry

DOI

10.1039/c8ob00398j

Abstract

Mercury is a highly toxic environmental pollutant that negatively affects human health. Thus, an in vivo method for noninvasive imaging of mercury(II) and visualization of its accumulation within living systems would be advantageous. Herein, we describe a reaction-based bioluminescent probe for detection of mercury(II) in vitro and accumulation in vivo. The application of this probe would help to shed light on the intricate contributions of mercury(II) to various physiological and pathological processes.

Recommended Citation

Ke, Bowen, Hui Chen, Li Ma, Sarah Zingales, Deying Gong, Die Hu, Lupei Du, Minyong Li. 2018. "Visualization of Mercury(II) Accumulation in Vivo Using Bioluminescence Imaging with a Highly Selective Probe." Organic and Biomolecular Chemistry, 16: 2388-2392. doi: 10.1039/c8ob00398j source: https://pubs.rsc.org/en/content/articlelanding/2018/OB/C8OB00398J#!divAbstract
https://digitalcommons.georgiasouthern.edu/chem-facpubs/107