Biostatistics, Epidemiology & Environmental Health Sciences: Faculty Publications
Statistical Considerations for Clinical Trials During COVID-19: A Two-Stage Adaptive Design for Clinical Trials in Patients with COVID-19 High Risks
Document Type
Article
Publication Date
4-13-2020
Publication Title
Abstract
Following the PARR strategy, the clinical trial can naturally be constructed as a two-stage adaptive design. The first stage is based on COVID-19 unaffected data from patients who are already enrolled. For clarification, patients enrolled who are affected by COVID-19 would contribute their data as censored observations in the first stage analysis. The second stage includes data from newly enrolled patients following a modified trial design for the remaining trial after post COVID-19.
Recommended Citation
Liu, Qing, Karl E. Peace.
2020.
"Statistical Considerations for Clinical Trials During COVID-19: A Two-Stage Adaptive Design for Clinical Trials in Patients with COVID-19 High Risks."
LinkedIn.
source: Linkedin.com
https://digitalcommons.georgiasouthern.edu/bee-facpubs/159
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