Biostatistics, Epidemiology & Environmental Health Sciences: Faculty Publications

Statistical Considerations for Clinical Trials During COVID-19: Impacts on Permuted Block Randomization and Mitigations

Document Type

Article

Publication Date

4-28-2020

Publication Title

LinkedIn

Abstract

Randomization is the foundation of any randomized controlled trial involving treatment comparisons. The major benefits of randomization in the context of clinical trials are:

  • Randomization helps mitigate various experimental biases.
  • It promotes comparability of treatment groups with respect to important known and unknown prognostic factors that may be correlated with the primary outcome.
  • It is the basis for the validity of standard statistical tests and makes the underlying assumptions of random sampling more plausible.
  • It can form the basis for statistical inference through re-randomization tests.

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