Typhoid Transmission: A Historical Perspective on Mathematical Model Development
Abstract or Description
Mathematical models of typhoid transmission have been developed for nearly half a century. To facilitate a better understanding of the historical development of this field, we reviewed mathematical models of typhoid and summarized their structures and limitations. Eleven models, published in 1971 to 2014, were reviewed. While models of typhoid vaccination are well developed, we highlight the need to better incorporate water, sanitation and hygiene interventions into models of typhoid and other foodborne and waterborne diseases. Mathematical modeling is a powerful tool to test and compare different intervention strategies which is important in the world of limited resources. By working collaboratively, epidemiologists and mathematicians can build better mathematical models of typhoid transmission that will be useful in epidemiological practice.
