Synthesis of Trifluoromethyl Ketones by (Diethylamino) Sulfur Trifluoride (DAST)-Mediated Nucleophilic Trifluoromethylation of Benzoic Acids

Name

Michael A. Vescio, Georgia Southern UniversityFollow

Publication Date

11-11-2022

Major

Biochemistry (B.S.)

Document Type and Release Option

Thesis (open access)

Faculty Mentor

Dr. Mohammed Abid Shaikh

Abstract

Within the past few decades, the presence of fluorine containing

organic molecules has increased significantly. Many of the

current industrial production methods are not cost-effective,

practical, or inherently safe. This work describes a new methodology

for the synthesis of trifluoromethyl ketones. Our new method involves

the use of benzoic acid and trifluoromethyl trimethylsilane (TMSCF₃) as starting

materials along with diethylamino sulfur trifluoride (DAST) as a reagent

to obtain moderate to good yields of expected products in a short

reaction times.

Recommended Citation

Vescio, Michael A., "Synthesis of Trifluoromethyl Ketones by (Diethylamino) Sulfur Trifluoride (DAST)-Mediated Nucleophilic Trifluoromethylation of Benzoic Acids" (2022). Honors College Theses. 800.
https://digitalcommons.georgiasouthern.edu/honors-theses/800