Microwave Synthesis and Characterization of Novel Triazole Derivative 2-[4-(3-fluoro-2-pyridinyl)-1h-1,2,3-triazol-1-yl]phenol
Faculty Mentor
Mark Vincent dela Cerna
Location
Savannah Ballroom
Type of Research
On-going
Session Format
Poster Presentation
College
College of Science & Mathematics
Department
Biochemistry, Chemistry and Physics
Abstract
Antimicrobial resistance is an escalating global health challenge that reduces the effectiveness of existing treatments and allows pathogens to persist and spread. One promising strategy to address this issue is the targeting of microbial protein tyrosine phosphatases (PTPs), which are enzymes that regulate signaling pathways involved in bacterial survival, adaptation and pathogenicity. As these enzymes influence cellular responses rather than essential metabolic processes, they represent attractive targets for developing nontraditional antimicrobial agents. Triazole compounds are particularly valuable in this context due to their structural stability, versatility and accessibility through click chemistry, as well as their ability to participate in metal coordination and enzyme binding. This project focuses on the design and synthesis of a triazole derivative to evaluate its potential as a microbial PTP inhibitor and to contribute to the broader development of new antimicrobial scaffolds.
Program Description
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Start Date
4-21-2026 1:30 PM
End Date
4-21-2026 3:30 PM
Recommended Citation
Chung-Samuels, Jada’Marie S.; dela Cerna, Mark Vincent; Landge, Shainaz; and Nguyen, Katie, "Microwave Synthesis and Characterization of Novel Triazole Derivative 2-[4-(3-fluoro-2-pyridinyl)-1h-1,2,3-triazol-1-yl]phenol" (2026). GS4 Student Scholars Symposium. 75.
https://digitalcommons.georgiasouthern.edu/research_symposium/2026A/2026A/75
Microwave Synthesis and Characterization of Novel Triazole Derivative 2-[4-(3-fluoro-2-pyridinyl)-1h-1,2,3-triazol-1-yl]phenol
Savannah Ballroom
Antimicrobial resistance is an escalating global health challenge that reduces the effectiveness of existing treatments and allows pathogens to persist and spread. One promising strategy to address this issue is the targeting of microbial protein tyrosine phosphatases (PTPs), which are enzymes that regulate signaling pathways involved in bacterial survival, adaptation and pathogenicity. As these enzymes influence cellular responses rather than essential metabolic processes, they represent attractive targets for developing nontraditional antimicrobial agents. Triazole compounds are particularly valuable in this context due to their structural stability, versatility and accessibility through click chemistry, as well as their ability to participate in metal coordination and enzyme binding. This project focuses on the design and synthesis of a triazole derivative to evaluate its potential as a microbial PTP inhibitor and to contribute to the broader development of new antimicrobial scaffolds.
