Presentation Title

Development of PEG and TEMPO Functionalised ROMP Monomers for Advances in the Treatment of Traumatic Brain Injuries

Location

Room 2905 A

Session Format

Paper Presentation

Research Area Topic:

Natural & Physical Sciences - Chemistry

Abstract

Development of PEG and TEMPO Functionalized ROMP Monomers for Advances in the Treatment of Traumatic Brain Injuries The goal of this research is on the development of ROMP (Ring Opening Metathesis Polymerization) polymers containing the functional groups 2,2,6,6- tertamethylpiperdin-1-oxyl (TEMPO) and polyethylene glycol (PEG). Both functional groups are known to have a detoxifying effect on cell-free hemoglobin. ROMP is a polymerization method that does not react with TEMPO and PEG. The polymers synthesized will then be bound to cell-free hemoglobin in an effort to treat traumatic brain injuries with hemoglobin that produces less reactive oxygen species (ROS). The advantage of such a blood substitute is that it should have a much longer shelf life than donor blood and would be compatible with any recipient. This project focuses on designing a synthesis that can bind these functionalities to a modified norbornene derivative using the Huisgen 1,3-cycloaddition reaction; also know as the click reaction. The ROMP works due to the boat conformation of the norbornene fragment, which lowers the ring tension of the bicyclic system when opened. In this context, we work on an optimized reaction protocol using a model azide to an endo-norbornene substrate containing an alkyne. The plan is to transfer these conditions to the coupling of the TEMPO and PEG functionalities to the endo-norbornenes and then using ROMP to synthesize our desired multifunctional polymers.

Presentation Type and Release Option

Presentation (Open Access)

Start Date

4-16-2016 4:00 PM

End Date

4-16-2016 5:00 PM

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Apr 16th, 4:00 PM Apr 16th, 5:00 PM

Development of PEG and TEMPO Functionalised ROMP Monomers for Advances in the Treatment of Traumatic Brain Injuries

Room 2905 A

Development of PEG and TEMPO Functionalized ROMP Monomers for Advances in the Treatment of Traumatic Brain Injuries The goal of this research is on the development of ROMP (Ring Opening Metathesis Polymerization) polymers containing the functional groups 2,2,6,6- tertamethylpiperdin-1-oxyl (TEMPO) and polyethylene glycol (PEG). Both functional groups are known to have a detoxifying effect on cell-free hemoglobin. ROMP is a polymerization method that does not react with TEMPO and PEG. The polymers synthesized will then be bound to cell-free hemoglobin in an effort to treat traumatic brain injuries with hemoglobin that produces less reactive oxygen species (ROS). The advantage of such a blood substitute is that it should have a much longer shelf life than donor blood and would be compatible with any recipient. This project focuses on designing a synthesis that can bind these functionalities to a modified norbornene derivative using the Huisgen 1,3-cycloaddition reaction; also know as the click reaction. The ROMP works due to the boat conformation of the norbornene fragment, which lowers the ring tension of the bicyclic system when opened. In this context, we work on an optimized reaction protocol using a model azide to an endo-norbornene substrate containing an alkyne. The plan is to transfer these conditions to the coupling of the TEMPO and PEG functionalities to the endo-norbornenes and then using ROMP to synthesize our desired multifunctional polymers.