Presentation Title

RNA Secondary Structure and Signaling Events

Location

Atrium

Session Format

Poster Presentation

Research Area Topic:

Natural & Physical Sciences - Chemistry

Co-Presenters, Co- Authors, Co-Researchers, Mentors, or Faculty Advisors

Dr. Jonathan Arambula and Kamaree J. Harris.

Abstract

Non-coding RNA secondary structures participate in signaling events within the transcriptome. In the case of some genetic mutations, intracellular communication and signaling fail to function properly. The development of chemical probes targeting RNA secondary structures may provide insight into intracellular interactions at the RNA level. Research is being conducted to create peptide nucleic acid-based oligomers incorporating natural and modified nucleobases. These oligomers are proposed to bind to hairpin loops via nucleic base recognition. The synthesis of these compounds is ongoing, and proposed binding studies are presented herein

Keywords

RNA, Signaling, Secondary structures, Intracellular communication

Presentation Type and Release Option

Presentation (Open Access)

Start Date

4-24-2015 2:45 PM

End Date

4-24-2015 4:00 PM

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Apr 24th, 2:45 PM Apr 24th, 4:00 PM

RNA Secondary Structure and Signaling Events

Atrium

Non-coding RNA secondary structures participate in signaling events within the transcriptome. In the case of some genetic mutations, intracellular communication and signaling fail to function properly. The development of chemical probes targeting RNA secondary structures may provide insight into intracellular interactions at the RNA level. Research is being conducted to create peptide nucleic acid-based oligomers incorporating natural and modified nucleobases. These oligomers are proposed to bind to hairpin loops via nucleic base recognition. The synthesis of these compounds is ongoing, and proposed binding studies are presented herein