RNA Secondary Structure and Signaling Events
Location
Atrium
Session Format
Poster Presentation
Research Area Topic:
Natural & Physical Sciences - Chemistry
Co-Presenters and Faculty Mentors or Advisors
Dr. Jonathan Arambula and Kamaree J. Harris.
Abstract
Non-coding RNA secondary structures participate in signaling events within the transcriptome. In the case of some genetic mutations, intracellular communication and signaling fail to function properly. The development of chemical probes targeting RNA secondary structures may provide insight into intracellular interactions at the RNA level. Research is being conducted to create peptide nucleic acid-based oligomers incorporating natural and modified nucleobases. These oligomers are proposed to bind to hairpin loops via nucleic base recognition. The synthesis of these compounds is ongoing, and proposed binding studies are presented herein
Keywords
RNA, Signaling, Secondary structures, Intracellular communication
Presentation Type and Release Option
Presentation (Open Access)
Start Date
4-24-2015 2:45 PM
End Date
4-24-2015 4:00 PM
Recommended Citation
Bizon, Connor J. Mr., "RNA Secondary Structure and Signaling Events" (2015). GS4 Georgia Southern Student Scholars Symposium. 95.
https://digitalcommons.georgiasouthern.edu/research_symposium/2015/2015/95
RNA Secondary Structure and Signaling Events
Atrium
Non-coding RNA secondary structures participate in signaling events within the transcriptome. In the case of some genetic mutations, intracellular communication and signaling fail to function properly. The development of chemical probes targeting RNA secondary structures may provide insight into intracellular interactions at the RNA level. Research is being conducted to create peptide nucleic acid-based oligomers incorporating natural and modified nucleobases. These oligomers are proposed to bind to hairpin loops via nucleic base recognition. The synthesis of these compounds is ongoing, and proposed binding studies are presented herein
