Presentation Title

Increased Conversion of Gold Salt into Gold Nanorods Having Various Aspect Ratios

Location

Room 2904 B

Session Format

Paper Presentation

Research Area Topic:

Natural & Physical Sciences - Chemistry

Co-Presenters, Co- Authors, Co-Researchers, Mentors, or Faculty Advisors

John W. Stone PhD

Abstract

A drastic increase in the use of gold nanoparticles as targeting, imaging, and therapeutic agents has occurred in the last decade. This increase is due to gold’s interesting optical properties, non-cytotoxicity, and long-term stability on the nanoscale. Gold nanoparticles having rod like morphology are among the most popular for these applications. These gold nanorods are prepared following a seed-mediated approach whereby gold salts are catalyzed by the addition of small gold spheres in the presence of a weak reducing agent and a growth directing surfactant. While this approach yields highly monodisperse solutions of gold nanorods the efficiency of the reaction is poor. We have demonstrated that by re-seeding the growth solution post centrifugation we can grow rods in multiple secondary reactions. Nanorods prepared from these secondary supernatants have similar physical and chemical properties as the originally prepared samples. By varying the amounts of the silver nitrate addition we are able to change the physical properties of the nanorods. We have found that performing the above process with multiple initial nanorod sizes gives similar results. Currently we are performing analyses to quantitate the conversion of gold from each of these re-seeded samples in order to ascertain the total conversion of gold from the original stock.

Keywords

Gold, Nanorods, Re-seeding, Conversion efficiency

Presentation Type and Release Option

Presentation (Open Access)

Start Date

4-24-2015 1:30 PM

End Date

4-24-2015 2:30 PM

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Apr 24th, 1:30 PM Apr 24th, 2:30 PM

Increased Conversion of Gold Salt into Gold Nanorods Having Various Aspect Ratios

Room 2904 B

A drastic increase in the use of gold nanoparticles as targeting, imaging, and therapeutic agents has occurred in the last decade. This increase is due to gold’s interesting optical properties, non-cytotoxicity, and long-term stability on the nanoscale. Gold nanoparticles having rod like morphology are among the most popular for these applications. These gold nanorods are prepared following a seed-mediated approach whereby gold salts are catalyzed by the addition of small gold spheres in the presence of a weak reducing agent and a growth directing surfactant. While this approach yields highly monodisperse solutions of gold nanorods the efficiency of the reaction is poor. We have demonstrated that by re-seeding the growth solution post centrifugation we can grow rods in multiple secondary reactions. Nanorods prepared from these secondary supernatants have similar physical and chemical properties as the originally prepared samples. By varying the amounts of the silver nitrate addition we are able to change the physical properties of the nanorods. We have found that performing the above process with multiple initial nanorod sizes gives similar results. Currently we are performing analyses to quantitate the conversion of gold from each of these re-seeded samples in order to ascertain the total conversion of gold from the original stock.