Synthesis of Trifluoromethyl Ketones by (Diethylamino) Sulfur Trifluoride (DAST)- Mediated Nucleophilic Trifluoromethylation of Benzoic Acids
Location
Statesboro Campus (Room 2054)
Document Type and Release Option
Thesis Presentation (Open Access)
Faculty Mentor
Dr. Mohammed Abid Shaikh
Faculty Mentor Email
malnu@georgiasouthern.edu
Presentation Year
2022
Start Date
16-11-2022 6:00 PM
End Date
16-11-2022 7:00 PM
Description
Within the past few decades, the presence of fluorine containing organic molecules has increased significantly. Many of the current industrial production methods are not cost-effective, practical, or inherently safe. This work describes a new methodology for the synthesis of trifluoromethyl ketones. Our new method involves the use of benzoic acid and trifluoromethyl trimethylsilane (TMSCF 3 ) as starting materials along with diethylamino sulfur trifluoride (DAST) as a reagent to obtain moderate to good yields of expected products in a short reaction times.
Academic Unit
College of Science and Mathematics
Synthesis of Trifluoromethyl Ketones by (Diethylamino) Sulfur Trifluoride (DAST)- Mediated Nucleophilic Trifluoromethylation of Benzoic Acids
Statesboro Campus (Room 2054)
Within the past few decades, the presence of fluorine containing organic molecules has increased significantly. Many of the current industrial production methods are not cost-effective, practical, or inherently safe. This work describes a new methodology for the synthesis of trifluoromethyl ketones. Our new method involves the use of benzoic acid and trifluoromethyl trimethylsilane (TMSCF 3 ) as starting materials along with diethylamino sulfur trifluoride (DAST) as a reagent to obtain moderate to good yields of expected products in a short reaction times.
