Designing Peptides to Bind kappa B DNA and Mimic NF-kappa B Protein Complexes
Location
Thesis Presentation- College of Science and Mathematics
Document Type and Release Option
Thesis Presentation (Archived)
Faculty Mentor
Dr. Amanda Stewart White
Faculty Mentor Email
.
Presentation Year
2020
Start Date
4-2020 12:00 AM
End Date
5-2020 12:00 AM
Keywords
Georgia Southern University, Honors Program, Thesis Presentation
Description
This research aims to design peptides capable of safely mimicking and inhibiting nuclear factor-kappa B transcription factors to regulate transcription and decrease overexpression. Three NF-κB peptide mimics were analyzed using isothermal titration calorimetry and fluorescence to study binding affinity to κB DNA. Circular dichroism was utilized to study their structures.
Academic Unit
College of Science and Mathematics
Designing Peptides to Bind kappa B DNA and Mimic NF-kappa B Protein Complexes
Thesis Presentation- College of Science and Mathematics
This research aims to design peptides capable of safely mimicking and inhibiting nuclear factor-kappa B transcription factors to regulate transcription and decrease overexpression. Three NF-κB peptide mimics were analyzed using isothermal titration calorimetry and fluorescence to study binding affinity to κB DNA. Circular dichroism was utilized to study their structures.
Comments
This work is archived and distributed under the repository's standard copyright and reuse license, available here. Under this license, end-users may copy, store, and distribute this work without restriction. For questions related to additional reuse of this work, please contact the copyright owner.