Date

2020

Major

Biology (B.S.B.)

Document Type and Release Option

Thesis (restricted to Georgia Southern)

Faculty Mentor

Dr. Dongyu Jia

Abstract

The common fruit fly, Drosophila melanogaster, is often used as a model organism in developmental biology and cancer biology. The processes that occur during oogenesis can be studied to gain insight into complex systems that are essential to development. The migration of border cells during stage 9 is one of these processes. In a prior project conceived by Dr. Denise Montell, the BTB domain protein, Abrupt, was analyzed for its role in border cell migration. Abrupt expression was shown to be utilized as a connecting point between the spatially centric signaling of JAK/STAT and the temporal signaling of ecdysone. A similar experimental design could be used to see if Broad, another BTB domain protein, could have a similar impact. Broad is of particular interest because in previous studies its expression has been shown to affect the timing of follicle cell development during oogenesis. Further analysis of border cell migration could shed light on the mechanisms that drive development.

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