Term of Award
Master of Science in Mathematics (M.S.)
Document Type and Release Option
Thesis (open access)
Department of Mathematical Sciences
Charles W. Champ
Committee Member 1
Committee Member 2
In the design of a clinical trial, the study of the effect of an intervention for a given medical condition is frequently of interest to researcher. Also, in recent years, the use of sequential and adaptive design methods in clinical research and development based on accrued data has become very popular due to its flexibility and efficiency. In this thesis, we derive the Behrens-Fisher distribution, and use the distributional result to examine the effect of an intervention by comparing population means of intervention group and control group. Sample size prediction methods proporting to solve the Behrens-Fisher problem are examined. A new method for solving the Behrens-Fisher problem is proposed. Various sequential and adaptive designs are reviewed.
Hu, Fengjiao, "Methods for Comparing Two Means with Application in Adaptive Clinical Trials" (2010). Electronic Theses & Dissertations. 660.